One Pan Cheesy Chicken Breast Casserole Recipe

This one-pan cheesy chicken breast casserole is easy, tasty, and perfect for busy nights. You only need one pan and a few basic ingredients. It’s great for families, meal prep, or when you need a comforting dinner without a lot of cleanup.

What makes this recipe a favorite:

• One-pan cooking saves time and reduces dishes
• Cheesy and creamy flavor that both kids and adults enjoy
• Quick to prepare, especially if using cooked or rotisserie chicken
• Flexible ingredients make it easy to customize
• Complete meal in one dish, with protein, carbs, and optional vegetables

This is the kind of meal you can throw together with what’s already in your fridge. It works for weeknights, lunch leftovers, or even to freeze ahead.

Also, Get an Easy BBQ Chicken Garbage Bread Recipe with Store-Bought Dough

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Ingredients You Will Need

You can use many pantry staples for this recipe. Here’s a basic list, plus some options to change it based on what you have.

Get more info about what ingredients you will need for One Pan Cheesy Chicken Breast Casserole, check bettycrocker.com

Basic Ingredients List

• Chicken breasts – Boneless and skinless. Diced or shredded.
• Shredded cheese – Cheddar is classic, but mozzarella or Monterey Jack work too.
• Cooked rice or pasta – White rice, brown rice, penne, or orzo are all good.
• Cream of mushroom or chicken soup – Makes the dish creamy and flavorful.
• Milk or heavy cream – Mixes with the soup to form a smooth base.
• Garlic and onion – Fresh or powdered, for extra flavor.
• Seasonings – Salt, pepper, paprika, dried oregano or thyme.

Tip: If you’re using raw chicken, increase baking time by 10–15 minutes to ensure it’s fully cooked.

Optional Add-ins and Substitutes

• Vegetables – Broccoli, peas, spinach, mushrooms, or frozen mixed veggies
• Other proteins – Cooked bacon, rotisserie chicken, or sliced sausage
• Soup alternative – Homemade roux or a mix of broth and cream
• Low-carb option – Use cauliflower rice instead of regular rice
• Dairy-free version – Swap milk and cheese with dairy-free alternatives

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Step-by-Step Instructions

This casserole is easy to build in one dish. You can prep it in 10 minutes and let the oven do the rest.

Step 1 – Preheat the Oven and Prepare Your Dish

• Preheat your oven to 375°F (190°C).
• Lightly grease a large oven-safe skillet, baking dish, or casserole dish.
• If using uncooked rice or pasta, cook it before starting the recipe.

Also find One Pot Creamy Tuscan Chicken Pasta with Garlic, Parmesan, and Herbs

Step 2 – Layer the Ingredients

• Add a layer of cooked rice or pasta to the bottom of the dish.
• Place your diced or shredded chicken breast evenly over the rice.
• In a separate bowl, whisk the cream soup and milk until smooth.
• Pour the soup mixture evenly over the chicken and rice.
• Sprinkle with garlic, onion, paprika, salt, pepper, and herbs.
• Top with a layer of shredded cheese.

Don’t stir it all together. Keep the cheese on top so it gets golden and bubbly in the oven.

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Step 3 – Bake and Finish

• Cover the dish with foil and bake for 20–25 minutes (if using cooked chicken).
• Remove the foil and bake or broil uncovered for 5 minutes to brown the cheese.
• If using raw chicken, bake for 35–40 minutes, or until chicken reaches 165°F (74°C).

Let the dish rest for 5 minutes before serving. This helps the cheese set and the flavors blend.

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Tips for Best Results

Let it rest before serving to avoid a runny texture.

Use cooked chicken to save time and ensure even cooking.- Cooked Chicken Nutrition – USDA FoodData Central

Grate cheese at home for better melting.

Cut the chicken evenly so it bakes at the same rate.

Taste before baking to check the seasoning.

Flavor Variations to Try

This recipe is flexible. You can change the flavor by adjusting a few ingredients. Here are some ideas:

Tex-Mex Chicken Casserole

• Add taco seasoning
• Include corn, black beans, and salsa
• Use a Mexican cheese blend

You can also find Quick and Easy Chicken Breast Recipes for First-Time Home Cooks

Buffalo Chicken Casserole

• Mix in buffalo sauce and ranch dressing
• Top with blue cheese crumbles

Mediterranean Chicken Bake

• Use feta cheese instead of cheddar
• Add olives, sun-dried tomatoes, and spinach

Italian-Style Casserole

• Add marinara sauce and Italian seasoning
• Use mozzarella and parmesan

These simple swaps let you keep the one-pan method while changing up the taste.

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What to Serve with This Casserole

While this casserole is a full meal on its own, you can serve it with a few simple sides to complete your dinner.

To learn more about what to serve with This Casserole, check out pillsbury.com

• Garlic bread – Adds crunch and helps scoop up cheesy bites
• Green salad – Offers a fresh contrast to the rich casserole
• Steamed vegetables – Broccoli, carrots, or green beans work well
• Pickles or coleslaw – Helps cut the creaminess with some acidity

You can also get here Three Ingredient Lemon Garlic Chicken Marinade for Oven or Grill

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Storage and Reheating Tips

This dish stores well and makes great leftovers.

• Refrigerate: Store leftovers in an airtight container for up to 4 days
• Freeze: Freeze portions in airtight containers for up to 2 months
• Reheat: Microwave individual portions, or bake covered in the oven at 350°F until hot

If frozen, thaw in the fridge overnight before reheating for best texture.

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Nutrition Information (Approximate)

This will vary depending on the ingredients you use, but here’s a general idea per serving:

• Calories: 400–500 kcal
• Protein: 30–35g
• Carbohydrates: 25–35g
• Fat: 15–20g
• Fiber: 1–3g

Use a nutrition calculator based on the exact brands and portions you use for more precise details.

Also know Fast and Easy Oven-Baked Chicken Breast That’s Perfectly Juicy

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Conclusion

This one-pan cheesy chicken breast casserole is everything you need in a cozy, easy dinner. It’s creamy, filling, and endlessly customizable. Whether you’re feeding picky kids or prepping for the week, this dish checks all the boxes.

It’s also a great recipe for busy families who want something home-cooked without spending all evening in the kitchen.